Anti-quorum sensing activity of natural compounds against Chromobacterium violaceum. 2016; 1(1): 43-48.

Abstract

The resistance and potential pathogenesis of bacteria could be related to their ability to sense and respond topopulation density, termed quorum-sensing (QS). Inhibition of the QS system is considered as a novel strategyfor development of antipathogenic agents, especially for combating bacterial infections caused by antibioticresistantstrains. In this work, the anti-QS activity of vanillin, geraniol and pomegranate extract was tested againstChromobacterium violaceum. Moreover, the minimum QS inhibitory concentration (MQSIC) was estimated foreach agent. MQSIC?s found were very low (0.60 mg/mL for vanillin; 0.19 µL/mL for geraniol; and 25 µg/mL forpomegranate extract). Therefore, the natural agents tested in this work are good candidates for the developmentof anti-QS compounds with potential application for the control of bacterial diseases regulated by QS systems.