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  • Miniatura
    Item type: Artículo ,
    Buenos Aires Breast Cancer Symposium 2024: Bridging basic and clinical research in breast cancer
    (Fundación Revista Medicina, 2025-05)
    Abba, Martín Carlos
    ;
    Behbod, Fariba
    ;
    Ceppi, Paolo
    ;
    Chammas, Roger
    ;
    Robert Clarke
    The second edition of the Buenos Aires Breast Cancer Symposium (BA-BCS), the first to be held in person, took place from September 3rd to 6th, 2024, in Buenos Aires, Argentina. Nineteen scientists from Brazil, Canada, the United States, the United Kingdom, Denmark, Germany, and Spain, along with six Argentine experts, shared and discussed their recent findings with the audience. Young researchers had the opportunity to present their results through either mini-oral presentations or posters, facilitating oneon-one interactions and the potential for new collaborations. This article summarizes each talk presented at the symposium.
  • Miniatura
    Item type: Artículo ,
    Quantifying the enzootic leukosis virus threat: how prevalent is the natural infection in Crioulo Lageano cattle in southern Brazil?
    (Instituto Internacional de Ecología, 2025-02)
    Fonteque, G. V.
    ;
    Casa, M. S.
    ;
    Ribeiro, G. S. N.
    ;
    Silva, Z.
    ;
    Vogel, C. I. G.
    Enzootic Bovine Leukosis (EBL), is infectious disease affecting especially older animals, although animals of all ages can be infected with the Bovine Leukemia Virus (BLV). Crioula Lageana is a locally adapted, rustic and long-lived bovine breed, important as a genetic resource. However, little is known about its health status, making it difficult to preserve the breed. In this sense, this study aims to assess the prevalence of EBL/BLV in different animal categories of Crioula Lageana cattle. Then, blood samples were collected from 308 animals from different categories: bulls, cows, heifers and male and female calves, whereby these animals were derived from six farms located in nuclei of in situ conservation for the Crioula Lageana breed in Planalto Serrano de Santa Catarina, Brazil and the blood samples were analyzed with hemogram, ELISA and PCR tests. There was a prevalence of 6.82% (21/308) for the ELISA test and 36.69% (113/308) for the PCR technique. There was no association between categories and natural infection or BLV positivity in PCR by the Chi-square test (P<0.05). Leukocytosis with lymphocytosis was observed in 11% (18/113) of PCR-positive animals. None of the evaluated animals presented bovine lymphosarcoma. We conclude that the BLV is present in all animal categories of the Crioula Lageana cattle, requiring the establishment of prevention and control measures to avoid the spread of the disease within herds.
  • Miniatura
    Item type: Artículo ,
    Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury
    (Wolters Kluwer, 2024-05)
    Cieri, María Belén
    ;
    Ramos, Alberto Javier
    Traumatic brain injury is a global health crisis, causing significant death and disability worldwide. Neuroinflammation that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments, with astrocytes involved in this response. Following traumatic brain injury, astrocytes rapidly become reactive, and astrogliosis propagates from the injury core to distant brain regions. Homeostatic astroglial proteins are downregulated near the traumatic brain injury core, while pro-inflammatory astroglial genes are overexpressed. This altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive recovery. In addition, glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration, but in the long term impedes axonal reconnection and functional recovery. Current therapeutic strategies for traumatic brain injury are focused on preventing acute complications. Statins, cannabinoids, progesterone, beta-blockers, and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of astrocytes. In this review, we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury, especially using cell-targeted strategies with miRNAs or lncRNA, viral vectors, and repurposed drugs.
  • Miniatura
    Item type: Artículo ,
    Encargados de edificio de Buenos Aires: Desigualdad, cuidados y gestión de las emociones
    (Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Estudios sobre Cultura y Sociedad, 2025-01)
    Canevaro, Santiago
    El artículo analiza el trabajo de los encargados de edificio de Buenos Aires a partir de reconocer la situación paradojal en la que se ubican en el entrecruzamiento de las esferas públicas y privadas. A partir de una indagación socio antropológica exploramos en la dimensión emocional y el trabajo relacional y de cuidados que realizan cotidianamente con sus empleadores. Centrados en las historias de vida de encargados que viven donde trabajan indagamos en la manera en que el clivaje afectivo y de cuidados se configura como un componente central del trabajo al mismo tiempo que define los contornos y marcos dentro de los cuales se procesan las relaciones de desigualdad. Posteriormente, mostramos la relevancia del espacio híbrido que supone las tareas que realizan los encargados en un espacio de trabajo y de intimidad que comparten con quienes son sus empleadores y que le otorga al vínculo que combina ambivalencia, complicidad y antagonismo.
  • Miniatura
    Item type: Artículo ,
    Phenolic Compounds and Fatty Acid Content of Some Extra Virgin Olive Oils from North-West of Argentina (La Rioja)
    (University of Zagreb. Faculty of Agriculture, 2024-05)
    Guzzonato, Agostina Lorena
    ;
    Nowakowski, Federico
    ;
    Ramirez, Maria Rosana
    Extra virgin olive oil (EVOO) is one of the most important vegetable oils from an economic and nutritional point of view. The health properties and oxidative stability of this oil depend on its chemical composition. However, these attributes are affected by the type of cultivar and the climate in which the olive trees are grown. This study was carried out to determine the fatty acid composition (FA) and the amount of polyphenols (PT) including hydroxytyrosol (HT) in 4 EVOO obtained from ‘Coratina’, ‘Arbequina’, ‘Barnea’ and oil blend (‘Barnea’ and ‘Arbequina’) varietals grown in a semi-arid region of northwestern Argentina. The ‘Coratina’ variety had a high oleic acid content (72.875%), and a higher monounsaturated and polyunsaturated fatty acids (MUFA/PUFA) ratio. PT values were significantly higher for the blend (280 mg/kg) than for ‘Arbequina’ (268 mg kg-1), ‘Barnea’ (248 mg kg-1) and ‘Coratina’ (210 mg kg-1). The HT content ranged from 3 mg kg-1 oil (‘Arbequina’) to 0.6 mg kg-1 oil (Blend). It is evident that all the oils analyzed contain nutritionally important elements which are determined by the varietal component of each one of them, and to a lesser extent by the soil and climatic conditions of the production region. These data could be useful to facilitate the selection of olive varieties planted in this semi-arid region, capable of producing EVOO with distinctive signs and better food quality.