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Artículo

Physicochemical, in vitro antioxidant and cytotoxic properties of water-soluble chitosan-lactose derivatives

Arata Badano, JoaquinIcon ; Vanden Braber, Noelia LucianaIcon ; Rossi, Yanina EstefaníaIcon ; Diaz Vergara, Ladislao IvanIcon ; Bohl, Luciana PaolaIcon ; Porporatto, CarinaIcon ; Falcone, Ruben DarioIcon ; Montenegro, Mariana AngélicaIcon
Fecha de publicación: 11/2019
Editorial: Elsevier
Revista: Carbohydrate Polymers
ISSN: 0144-8617
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica

Resumen

In this study, water-soluble chitosan (Ch) derivatives were synthesized by the Maillard reaction between Ch and lactose. The Ch derivatives were characterized by FT-IR, 1H-NMR and SLS to determine their structure, degree of deacetylation (DD), and molecular weight (Mw). The solubility at physiological pH, the in vitro antioxidant activity against hydroxyl radical, anion superoxide radical and ABTS cation radical, and the cytotoxicity against epithelial cells of therat ileum (IEC-18) were also evaluated. The Maillard reaction, derivatives with lower Mw and DD and greater solubility than Ch were obtained. The biological properties of the derivatives were dependent on the concentration, Mw and DD, with antioxidant activity greater than or equal to that of Ch and non-cytotoxic in a wide range of concentrations. The results indicate that Ch derivatization with lactose produces new water-soluble polysaccharides, with antioxidantactivity and non-cytotoxic, which can be used as biomaterials for food and pharmaceutical applications.
Palabras clave: Chitosan-Lactose derivatives , Maillard reaction , Antioxidant activity , Cytotoxicity , Chitosan-Lactose derivatives , Antioxidant activity
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/106554
URL: https://www.sciencedirect.com/science/article/abs/pii/S0144861719308252
DOI: https://doi.org/10.1016/j.carbpol.2019.115158
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Arata Badano, Joaquin; Vanden Braber, Noelia Luciana; Rossi, Yanina Estefanía; Diaz Vergara, Ladislao Ivan; Bohl, Luciana Paola; et al.; Physicochemical, in vitro antioxidant and cytotoxic properties of water-soluble chitosan-lactose derivatives; Elsevier; Carbohydrate Polymers; 224; 11-2019
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