Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
; Barrio Real, Laura ; Abera, Mahlet B ; Lopez Haber, Cynthia ; Rosemblit, Cinthia ; Lu, Huaisheng ; Abba, Martín Carlos ; Kazanietz, Marcelo G. Otros responsables
Fecha
07/2014
Editorial
American Society for Biochemistry and Molecular Biology
Revista
Journal Of Biological Chemistry (online)
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ISSN
1083-351X
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Inglés
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Resumen
Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
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Excepto donde se indique lo contrario, la licencia de este ítem se describe como by-nc-sa
Identificadores
Lopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-19838
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