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Artículo

Folate-producing lactic acid bacteria reduce inflammation in mice with induced intestinal mucositis

Levit, RominaIcon ; Savoy, GracielaIcon ; de Moreno, Maria AlejandraIcon ; Leblanc, Jean Guy JosephIcon
Fecha de publicación: 03/07/2018
Editorial: Wiley Blackwell Publishing, Inc
Revista: Journal of Applied Microbiology
ISSN: 1364-5072
e-ISSN: 1365-2672
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Aim: To evaluate two folate-producing strains, Streptococcus (Strep.) thermophilus CRL 808 and Strep. thermophilus CRL 415, against chemically induced mucositis in mice. Methods and Results: In vitro assays with Caco-2 cells were performed to evaluate the effect of the bacteria in the presence of 5-fluorouracil (5-FU). For in vivo studies, mice were daily injected with 5-FU to induce intestinal mucositis (IM) and orally administered with folate-producing strains during 6 days. Clinical symptoms, histological parameters and cytokine profiles were assessed. The results showed that Strep. thermophilus CRL 808 increased the cytotoxicity of 5-FU against Caco-2 cells. Administration of this strain in mice with chemically induced IM resulted in a reduction in diarrhoea score and restoration of the intestinal architecture. Cytokine analysis showed that the anti-inflammatory effect by the bacterium is not associated with an immune mechanism. Regarding Strep. thermophilus CRL 415, no improvements were observed in any of the parameters evaluated. Conclusion: The administration of the folate-producing Strep. thermophilus CRL 808 has the potential to prevent IM induced by 5-FU in mice. Significance and Impact of the Study: Folate-producing LAB could be used in chemotherapy patients to reduce the symptoms of IM, improve their nutritional status and increase the effectiveness of 5-FU.
Palabras clave: 5-Fluorouracil , Chemotherapy , Folate , Inflammation , Lactic Acid Bacteria , Mucositis , Probiotic
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/82630
DOI: https://dx.doi.org/http://doi.wiley.com/10.1111/jam.14038
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jam.14038
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Articulos(CERELA) [833]
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Levit, Romina; Savoy, Graciela; de Moreno, Maria Alejandra; Leblanc, Jean Guy Joseph; Folate-producing lactic acid bacteria reduce inflammation in mice with induced intestinal mucositis; Wiley Blackwell Publishing, Inc; Journal of Applied Microbiology; 125; 5; 3-7-2018; 1494-1501
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