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Artículo

Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice

Levit, RominaIcon ; Savoy, GracielaIcon ; de Moreno, Maria AlejandraIcon ; Leblanc, Jean Guy JosephIcon
Fecha de publicación: 10/2018
Editorial: Elsevier
Revista: Nutrition
ISSN: 0899-9007
e-ISSN: 1873-1244
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Alimentos y Bebidas

Resumen

Objective: Intestinal mucositis (IM), a side effect commonly associated to cancer treatments, is a local inflammatory response that causes alterations of the intestinal structure that in turn affects nutrient absorption. Lactobacillus (L.) plantarum CRL 2130 is a riboflavin-overproducing strain that has previously been shown to provide anti-inflammatory properties. The objective of this study was to evaluate the effects of this riboflavin producing strain in a chemically induced murine mucositis model. Research Methods & Procedures: Mucositis was induced by daily injections of 5-fluororacil (5-FU) after which mice were either given L. plantarum CRL 2130, L. plantarum CRL 725 (the strain from which CRL 2130 was derived that does not overproduce riboflavin), or commercial riboflavin twice daily during the 6 days of chemotherapy agent injections. The effect of the strains and riboflavin was also evaluated in vitro using Caco-2 intestinal cancer cell cultures to determine if they interfere with 5-FU´s anti-cancer activity. Results: Administration of L. plantarum CRL 2130 significantly attenuated the pathological changes induced by 5-FU in mice such as body weight loss, diarrhea, the shortening of villus height, increases in proinflammatory cytokine concentrations, and induced an elevated production of IL-10. In vitro assays using Caco-2 cells showed that the effectiveness of 5-FU was not affected by L. plantarum CRL 2130 and that this strain exerted an inhibitory mechanism against oxidative stress. Conclusion: These results indicate that the riboflavin-overproducing strain L. plantarum CRL 2130 could be useful to prevent mucositis during cancer treatments and would not affect the primary treatment.
Palabras clave: Lactic Acid Bacteria , Mucositis , Fluorouracil , Riboflavin , 5-Fluorouracil
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/81442
DOI: https://dx.doi.org/10.1016/j.nut.2018.03.056
URL: https://www.sciencedirect.com/science/article/pii/S0899900718302648?via%3Dihub
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Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Levit, Romina; Savoy, Graciela; de Moreno, Maria Alejandra; Leblanc, Jean Guy Joseph; Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice; Elsevier; Nutrition; 54; 10-2018; 165-172
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