Artículo
Lactobacillus reuteri CRL 1098 and Lactobacillus acidophilus CRL 1014 differently reduce in vitro immunotoxic effect induced by Ochratoxin A
Mechoud, Monica Adriana
; Juarez, Guillermo Esteban
; Font, Graciela Maria
; Rodriguez, Ana Virginia
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Fecha de publicación:
05/12/2012
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Food And Chemical Toxicology
ISSN:
0278-6915
e-ISSN:
1873-6351
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Ochratoxin A (OTA) is a widespread mycotoxin contaminating several food products which causes detrimental health effects. The ability of Lactobacillus reuteri CRL 1098 and Lactobacillus acidophilus CRL 1014 to prevent OTA effects on TNF-α and IL-10 production and apoptosis induction in human peripheral blood mononuclear cells (PBMC) was investigated. Membrane rafts participation in these responses was also evaluated. L. reuteri reduced by 29% the OTA inhibition of TNF-α production whereas L. acidophilus increased 8 times the TNF-α production by OTA treated-PBMC. Also, both bacteria reversed apoptosis induced by OTA by 32%. However, neither of the bacteria reversed the OTA inhibition on IL-10 production. On the other hand, the lactobacilli were less effective to reverse OTA effects on disrupted-rafts PBMC. This study shows that two lactobacilli strains can reduce some negative OTA effects, being membrane rafts integrity necessary to obtain better results. Also, the results highlight the potential capacity of some lactobacilli strains usually included in natural dietary components in milk-derived products and cereals feed, to reduce OTA toxicity once ingested by humans or animals.
Palabras clave:
Apoptosis
,
Cytokines
,
Lactobacilli
,
Membrane Rafts
,
Ochratoxin A
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Mechoud, Monica Adriana; Juarez, Guillermo Esteban; Font, Graciela Maria; Rodriguez, Ana Virginia; Lactobacillus reuteri CRL 1098 and Lactobacillus acidophilus CRL 1014 differently reduce in vitro immunotoxic effect induced by Ochratoxin A; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 50; 12; 5-12-2012; 4310-4315
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