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Artículo

Antibacterial activity of naringin derivatives against pathogenic strains

Celiz, GustavoIcon ; Daz, Mirta Elizabeth; Audisio, Marcela CarinaIcon
Fecha de publicación: 09/2011
Editorial: Wiley Blackwell Publishing, Inc
Revista: Journal of Applied Microbiology
ISSN: 1364-5072
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Aims: To study the antimicrobial activity of naringin (NAR), a flavonoid extracted from citrus industry waste, and NAR derivatives [naringenin (NGE), prunin and alkyl prunin esters] against pathogenic bacteria such as L. monocytogenes, E. coli O157:H7 and S. aureus. The relationship between the structure of the chemical compounds and their antagonistic effect was also analysed. Methods and Results: The agar dilution technique and direct contact assaying were applied. NGE, prunin and NAR showed no antimicrobial activity at a concentration of 0.25mmoll -1. Similarly, fatty acids with a chain length between C2 and C18 showed no antimicrobial activity at the same concentration. However, prunin-6″-O-acyl esters presented high antibacterial activity, mainly against Gram-positive strains. This activity increased with increasing chain length (up to 10-12 carbon atoms). Alkyl prunin esters with 10-12 carbon atoms diminished viability of L. monocytogenes by about 3log orders and S. aureus by 6log orders after 2h of contact at 37°C and at a concentration of 0.25mmoll -1. The compounds examined were not effective against any of the Gram-negative strains assayed, even at the highest concentration. Conclusions: Addition of sugars to the aglycone did not enhance its antimicrobial activity. Attachment of a saturated aliphatic chain with 10-12 carbon atoms to the A ring of the flavonoid (or to sugars attached to this ring), seems to be the most promising modification. In conclusion, alkyl prunin esters with a chain length of C10-C12have promising features as antimicrobial agents because of their high antilisterial and antistaphylococcal activity. Significance and Impact of the Study: This study shows that it is possible to obtain NAR derivatives with important antimicrobial activity, especially against Gram-positive pathogenic bacteria. It also provides guidelines on the structural modifications in similar molecules to enhance the antimicrobial activity. © 2011 The Authors. Journal of Applied Microbiology © 2011 The Society for Applied Microbiology.
Palabras clave: Antibacterial Activity , Flavonoid Esters , Listeria Monocytogenes , Naringin , Staphylococcus Aureus Atcc29213
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/61774
DOI: https://dx.doi.org/10.1111/j.1365-2672.2011.05070.x
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2672.2011.05070.x
Colecciones
Articulos(INIQUI)
Articulos de INST.DE INVEST.PARA LA INDUSTRIA QUIMICA (I)
Citación
Celiz, Gustavo; Daz, Mirta Elizabeth; Audisio, Marcela Carina; Antibacterial activity of naringin derivatives against pathogenic strains; Wiley Blackwell Publishing, Inc; Journal of Applied Microbiology; 111; 3; 9-2011; 731-738
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