Artículo
Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir
Fecha de publicación:
21/04/2006
Editorial:
Academic Press Ltd - Elsevier Science Ltd
Revista:
Cytokine
ISSN:
1043-4666
e-ISSN:
1096-0023
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Previous studies have shown that compounds released during milk fermentation by Lactobacillus helveticus are implicated in the antitumour effect of this product. Here the effects of the consumption, during 2 or 7 days, of kefir or kefir cell-free fraction (KF) on the systemic and local immune responses in mammary glands and tumours using a murine hormone-dependent breast cancer model were studied. In the tumour control group, mice did not receive these products. At the end of the feeding period, mice were injected subcutaneously with tumour cells in the mammary gland. Four days post-injection, they received kefir or KF on a cyclical basis. Rate of tumour development, cytokines in serum; mammary gland tissue, and tumour isolated cells were monitored. Two-day cyclical administration of both products delayed tumour growth. Both kefir and KF increased IL-10 in serum and decreased IL-6(+) cells (cytokine involved in oestrogen synthesis) in mammary glands. Two-day cyclical administration of KF increased IL-10(+) cells in mammary glands and in tumours and decreased IL-6(+) cells in tumour. This study demonstrated the modulatory capacity of KF on the immune response in mammary glands and tumours and the importance of the administration period to obtain this effect.
Palabras clave:
Breast Cancer
,
Immune Response
,
Kefir
Archivos asociados
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Identificadores
Colecciones
Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
de Moreno, Maria Alejandra; Matar, Chantal; Farnworth, E.; Perdigon, Gabriela del Valle; Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 34; 1-2; 21-4-2006; 1-8
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