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dc.contributor.author
de Moreno, Maria Alejandra
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dc.contributor.author
Matar, Chantal
dc.contributor.author
Farnworth, E.
dc.contributor.author
Perdigon, Gabriela del Valle
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dc.date.available
2018-08-21T21:41:59Z
dc.date.issued
2006-04-21
dc.identifier.citation
de Moreno, Maria Alejandra; Matar, Chantal; Farnworth, E.; Perdigon, Gabriela del Valle; Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 34; 1-2; 21-4-2006; 1-8
dc.identifier.issn
1043-4666
dc.identifier.uri
http://hdl.handle.net/11336/56497
dc.description.abstract
Previous studies have shown that compounds released during milk fermentation by Lactobacillus helveticus are implicated in the antitumour effect of this product. Here the effects of the consumption, during 2 or 7 days, of kefir or kefir cell-free fraction (KF) on the systemic and local immune responses in mammary glands and tumours using a murine hormone-dependent breast cancer model were studied. In the tumour control group, mice did not receive these products. At the end of the feeding period, mice were injected subcutaneously with tumour cells in the mammary gland. Four days post-injection, they received kefir or KF on a cyclical basis. Rate of tumour development, cytokines in serum; mammary gland tissue, and tumour isolated cells were monitored. Two-day cyclical administration of both products delayed tumour growth. Both kefir and KF increased IL-10 in serum and decreased IL-6(+) cells (cytokine involved in oestrogen synthesis) in mammary glands. Two-day cyclical administration of KF increased IL-10(+) cells in mammary glands and in tumours and decreased IL-6(+) cells in tumour. This study demonstrated the modulatory capacity of KF on the immune response in mammary glands and tumours and the importance of the administration period to obtain this effect.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Ltd - Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Breast Cancer
dc.subject
Immune Response
dc.subject
Kefir
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T18:16:40Z
dc.identifier.eissn
1096-0023
dc.journal.volume
34
dc.journal.number
1-2
dc.journal.pagination
1-8
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: de Moreno, Maria Alejandra. Université de Moncton. Départment de Chimie-Biochimie; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Matar, Chantal. Université de Moncton. Départment de Chimie-Biochimie; Canadá
dc.description.fil
Fil: Farnworth, E.. Agriculture and Agri-Food; Canadá
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.journal.title
Cytokine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cyto.2006.03.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043466606001232
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