Artículo

C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases

Riafrecha, Leonardo EzequielIcon ; Vullo, Daniela; Supuran, Claudiu T.; Colinas, Pedro AlfonsoIcon
Fecha de publicación: 09/2015
Editorial: Taylor & Francis
Revista: Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN: 1475-6366
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from Cryptococcus neoformans and Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. The deprotected glycosides incorporating the 6-methoxy-2-naphthyl moiety showed the best inhibition profile and therefore represent leads for the development of novel anti-infectives with a new mechanism of action.
Palabras clave: Carbohydrate , Carbonic Anhydrase , Pathogen
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/53460
DOI: http://dx.doi.org/10.3109/14756366.2014.967233
URL: https://www.tandfonline.com/doi/abs/10.3109/14756366.2014.967233
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Riafrecha, Leonardo Ezequiel; Vullo, Daniela; Supuran, Claudiu T.; Colinas, Pedro Alfonso; C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases; Taylor & Francis; Journal of Enzyme Inhibition and Medicinal Chemistry; 30; 5; 9-2015; 857-861
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