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dc.contributor.author
Riafrecha, Leonardo Ezequiel  
dc.contributor.author
Vullo, Daniela  
dc.contributor.author
Supuran, Claudiu T.  
dc.contributor.author
Colinas, Pedro Alfonso  
dc.date.available
2018-07-30T18:52:06Z  
dc.date.issued
2015-09  
dc.identifier.citation
Riafrecha, Leonardo Ezequiel; Vullo, Daniela; Supuran, Claudiu T.; Colinas, Pedro Alfonso; C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases; Taylor & Francis; Journal of Enzyme Inhibition and Medicinal Chemistry; 30; 5; 9-2015; 857-861  
dc.identifier.issn
1475-6366  
dc.identifier.uri
http://hdl.handle.net/11336/53460  
dc.description.abstract
A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from Cryptococcus neoformans and Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. The deprotected glycosides incorporating the 6-methoxy-2-naphthyl moiety showed the best inhibition profile and therefore represent leads for the development of novel anti-infectives with a new mechanism of action.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/  
dc.subject
Carbohydrate  
dc.subject
Carbonic Anhydrase  
dc.subject
Pathogen  
dc.subject.classification
Otras Ciencias Químicas  
dc.subject.classification
Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-07-30T13:38:28Z  
dc.journal.volume
30  
dc.journal.number
5  
dc.journal.pagination
857-861  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Riafrecha, Leonardo Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Vullo, Daniela. Università degli Studi di Firenze; Italia  
dc.description.fil
Fil: Supuran, Claudiu T.. Università degli Studi di Firenze; Italia  
dc.description.fil
Fil: Colinas, Pedro Alfonso. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Journal of Enzyme Inhibition and Medicinal Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/14756366.2014.967233  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/14756366.2014.967233  

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