Artículo

The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia BelenIcon ; Berkov, Strahil; Font-Bardia, Mercè; Calvet, Teresa; Konrath, Eduardo Luis; Bueno, Kelly; Sachett, Liana G.; Dutilh, Julie H.; de Souza Borges, Warley; Viladomat, Francesc; Henriques, Amelia T.; Nair, Jerald J.; Zuanazzi, José Angelo S.; Bastida, Jaume
Fecha de publicación: 02/2016
Editorial: Springer
Revista: Phytochemistry Reviews
ISSN: 1568-7767
e-ISSN: 1572-980X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
Palabras clave: Galanthamine , Gc-Ms , Hippeastrum , Sanguinine , X-Ray Crystallography
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/48792
URL: http://link.springer.com/article/10.1007%2Fs11101-015-9411-7
DOI: http://dx.doi.org/10.1007/s11101-015-9411-7
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Articulos(ICYTAC)
Articulos de INST. DE CIENCIA Y TECNOLOGIA DE ALIMENTOS CORDOBA
Citación
de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia Belen; Berkov, Strahil; et al.; The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids; Springer; Phytochemistry Reviews; 15; 1; 2-2016; 147-160
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