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dc.contributor.author
de Andrade, Jean Paulo
dc.contributor.author
Giordani, Raquel B.
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Torras-Claveria, Laura
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Pigni, Natalia Belen
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Berkov, Strahil
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Font-Bardia, Mercè
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Calvet, Teresa
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Konrath, Eduardo Luis
dc.contributor.author
Bueno, Kelly
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Sachett, Liana G.
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Dutilh, Julie H.
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de Souza Borges, Warley
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Viladomat, Francesc
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Henriques, Amelia T.
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Nair, Jerald J.
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Zuanazzi, José Angelo S.
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Bastida, Jaume
dc.date.available
2018-06-15T16:56:47Z
dc.date.issued
2016-02
dc.identifier.citation
de Andrade, Jean Paulo; Giordani, Raquel B.; Torras-Claveria, Laura; Pigni, Natalia Belen; Berkov, Strahil; et al.; The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids; Springer; Phytochemistry Reviews; 15; 1; 2-2016; 147-160
dc.identifier.issn
1568-7767
dc.identifier.uri
http://hdl.handle.net/11336/48792
dc.description.abstract
Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC?MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Galanthamine
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Gc-Ms
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Hippeastrum
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Sanguinine
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X-Ray Crystallography
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-12T18:38:25Z
dc.identifier.eissn
1572-980X
dc.journal.volume
15
dc.journal.number
1
dc.journal.pagination
147-160
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: de Andrade, Jean Paulo. Universidad de Barcelona; España. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; Brasil
dc.description.fil
Fil: Giordani, Raquel B.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Torras-Claveria, Laura. Universidad de Barcelona; España. Universidad del Espiritu Santo; Brasil
dc.description.fil
Fil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Berkov, Strahil. Universidad de Barcelona; España. AgroBioInstitute; Bulgaria. Universidad del Espiritu Santo; Brasil
dc.description.fil
Fil: Font-Bardia, Mercè. Universidad de Barcelona; España
dc.description.fil
Fil: Calvet, Teresa. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Konrath, Eduardo Luis. Universidade Federal do Rio Grande do Sul; Brasil. Universidad del Espiritu Santo; Brasil
dc.description.fil
Fil: Bueno, Kelly. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Sachett, Liana G.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Dutilh, Julie H.. Universidade Estadual de Campinas; Brasil. Universidad del Espiritu Santo; Brasil
dc.description.fil
Fil: de Souza Borges, Warley. Universidad del Espiritu Santo; Brasil
dc.description.fil
Fil: Viladomat, Francesc. Universidad de Barcelona; España
dc.description.fil
Fil: Henriques, Amelia T.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Nair, Jerald J.. Universidad de Barcelona; España
dc.description.fil
Fil: Zuanazzi, José Angelo S.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Bastida, Jaume. Universidad de Barcelona; España
dc.journal.title
Phytochemistry Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs11101-015-9411-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11101-015-9411-7
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