Artículo
Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
Riafrecha, Leonardo Ezequiel
; Vullo, Daniela; Ouahrani Bettache, Safia; Köhler, Stephan; Dumy, Pascal; Winum, Jean Yves; Supuran, Claudiu T.; Colinas, Pedro Alfonso
; Vullo, Daniela; Ouahrani Bettache, Safia; Köhler, Stephan; Dumy, Pascal; Winum, Jean Yves; Supuran, Claudiu T.; Colinas, Pedro Alfonso
Fecha de publicación:
11/2015
Editorial:
Taylor & Francis Ltd
Revista:
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN:
1475-6366
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. Glycosides incorporating the 3-hydroxyphenyl moiety showed the best inhibition profile, and therefore this functionality represents lead for the development of novel anti-infectives with a new mechanism of action.
Palabras clave:
ANTIBACTERIAL
,
CARBOHYDRATE
,
CARBONIC ANHYDRASE
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536.1Kb
Formato:
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Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Riafrecha, Leonardo Ezequiel; Vullo, Daniela; Ouahrani Bettache, Safia; Köhler, Stephan; Dumy, Pascal; et al.; Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety; Taylor & Francis Ltd; Journal of Enzyme Inhibition and Medicinal Chemistry; 30; 6; 11-2015; 1017-1020
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