Mostrar el registro sencillo del ítem
dc.contributor.author
Riafrecha, Leonardo Ezequiel
dc.contributor.author
Vullo, Daniela
dc.contributor.author
Ouahrani Bettache, Safia
dc.contributor.author
Köhler, Stephan
dc.contributor.author
Dumy, Pascal
dc.contributor.author
Winum, Jean Yves
dc.contributor.author
Supuran, Claudiu T.
dc.contributor.author
Colinas, Pedro Alfonso
dc.date.available
2018-03-22T15:43:02Z
dc.date.issued
2015-11
dc.identifier.citation
Riafrecha, Leonardo Ezequiel; Vullo, Daniela; Ouahrani Bettache, Safia; Köhler, Stephan; Dumy, Pascal; et al.; Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety; Taylor & Francis Ltd; Journal of Enzyme Inhibition and Medicinal Chemistry; 30; 6; 11-2015; 1017-1020
dc.identifier.issn
1475-6366
dc.identifier.uri
http://hdl.handle.net/11336/39664
dc.description.abstract
A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. Glycosides incorporating the 3-hydroxyphenyl moiety showed the best inhibition profile, and therefore this functionality represents lead for the development of novel anti-infectives with a new mechanism of action.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
ANTIBACTERIAL
dc.subject
CARBOHYDRATE
dc.subject
CARBONIC ANHYDRASE
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-22T13:04:02Z
dc.journal.volume
30
dc.journal.number
6
dc.journal.pagination
1017-1020
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Riafrecha, Leonardo Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina
dc.description.fil
Fil: Vullo, Daniela. Universita Degli Studi Di Firenze; Italia
dc.description.fil
Fil: Ouahrani Bettache, Safia. Université Montpellier; Francia
dc.description.fil
Fil: Köhler, Stephan. Université Montpellier; Francia
dc.description.fil
Fil: Dumy, Pascal. Ecole Nationale Supérieure de Chimie de Montpellier; Francia
dc.description.fil
Fil: Winum, Jean Yves. Ecole Nationale Supérieure de Chimie de Montpellier; Francia
dc.description.fil
Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia
dc.description.fil
Fil: Colinas, Pedro Alfonso. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina
dc.journal.title
Journal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/14756366.2014.986120
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/14756366.2014.986120
Archivos asociados
Tamaño:
536.1Kb
Formato:
PDF