Artículo
Influence of a probiotic lactobacillus strain on the intestinal ecosystem in a stress model mouse
Fecha de publicación:
01/2014
Editorial:
Academic Press Inc Elsevier Science
Revista:
Brain Behavior And Immunity
ISSN:
0889-1591
e-ISSN:
1090-2139
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Daily exposure to stressful situations affects the health of humans and animals. It has been shown that psychological stress affects the immune system and can exacerbate diseases. Probiotics can act as biological immunomodulators in healthy people, increasing both intestinal and systemic immune responses. The use of probiotics in stress situations may aid in reinforcing the immune system. The aim of this study was to evaluate the effect of a probiotic bacterium on the gut immune system of mice that were exposed to an experimental model of stress induced by food and mobility restriction. The current study focused on immune cells associated with the lamina propria of the intestine, including CD4+ and CD8+ T lymphocytes, CD11b+ macrophages, CD11c+ dendritic cells, and IgA+ B lymphocytes, as well as the concentrations of secretory IgA (S-IgA) and cytokine interferon gamma (INF-c in intestinal fluid. We also evaluated the probiotic?s influence on the gut microbiota. Probiotic administration increased IgA producing cells, CD4+ cells in the lamina propria of the small intestine, and S-IgA in the lumen; it also reduced the levels of IFN-c that had increased during stress and improved the intestinal microbiota as measured by an increase in the lactobacilli population. The results obtained from administration of the probiotic to stressed mice suggest that the use of food containing these microorganisms may work as a palliative to reinforce the immune system.
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Identificadores
Colecciones
Articulos(CCT - NOA SUR)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Palomar, Martín Manuel; Maldonado Galdeano, María Carolina; Perdigón, Gabriela del Valle; Influence of a probiotic lactobacillus strain on the intestinal ecosystem in a stress model mouse; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 35; 1-2014; 77-85
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