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Artículo

Physicochemical characterization of water-soluble chitosan derivatives with singlet oxygen quenching and antibacterial capabilities

Vanden Braber, Noelia LucianaIcon ; Diaz Vergara, Ladislao IvanIcon ; Moran Vieyra, Faustino EduardoIcon ; Borsarelli, Claudio DaríoIcon ; Yossen, Mariana MatildeIcon ; Vega, Jorge RubenIcon ; Correa, Silvia GracielaIcon ; Montenegro, Mariana AngélicaIcon
Fecha de publicación: 04/2017
Editorial: Elsevier Science
Revista: International Journal of Biological Macromolecules
ISSN: 0141-8130
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas; Bioquímica y Biología Molecular

Resumen

New water-soluble chitosan derivatives (WSCh) were obtained by Maillard reaction (MR) between glucosamine (GA) with both low and medium molecular weight chitosans (Ch). The WSCh showed larger solubility than the respective Ch, while their deacetylation degree (DD) decreased by approximately 12%. Infrared spectroscopy experiments of WSCh confirmed the formation of imine bonds after MR with intensified pyranose structure, and sugar molecules as polymer branches. However, a 6-times reduction of the molecular weight of WSCh was measured, indicating the breakdown of the polysaccharide chain during the MR. The polysaccharides quenched singlet molecular oxygen (1O2), with rate quenching constants correlating with the DD value of the samples, suggesting the important role of amino groups (−NH2) in the deactivation of 1O2. Additionally, all polysaccharides presented antimicrobial activity against pathogenic bacteria, e.g. Staphylococcus aureus, Escherichia coli, Salmonella sp., Enterococcus faecalis and Listeria ivanovii, as tested by their minimum inhibitory concentration (MIC). This way we obtained new water-soluble polysaccharides, with similar functional properties to those presented by native Ch, enhancing its potential application as carrier material for bioactive compounds.
Palabras clave: Water-Soluble Chitosans , Singlet Oxygen Quenching , Antimicrobial Activity
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info:eu-repo/semantics/embargoedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/23948
DOI: http://dx.doi.org/10.1016/j.ijbiomac.2017.04.028
URL: http://www.sciencedirect.com/science/article/pii/S0141813016321493
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos(INBIONATEC)
Articulos de INSTITUTO DE BIONANOTECNOLOGIA DEL NOA
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Vanden Braber, Noelia Luciana; Diaz Vergara, Ladislao Ivan; Moran Vieyra, Faustino Eduardo; Borsarelli, Claudio Darío; Yossen, Mariana Matilde; et al.; Physicochemical characterization of water-soluble chitosan derivatives with singlet oxygen quenching and antibacterial capabilities; Elsevier Science; International Journal of Biological Macromolecules; 102; 4-2017; 200-207
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