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dc.contributor.author
León Vargas, Fabian
dc.contributor.author
Garelli, Fabricio
dc.contributor.author
de Battista, Hernan
dc.contributor.author
Vehí, Josep
dc.date.available
2017-08-25T20:40:40Z
dc.date.issued
2013-08
dc.identifier.citation
León Vargas, Fabian; Garelli, Fabricio; de Battista, Hernan; Vehí, Josep; Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation; Elsevier; Biomedical Signal Processing And Control; 8; 6; 8-2013; 724-736
dc.identifier.issn
1746-8094
dc.identifier.uri
http://hdl.handle.net/11336/23045
dc.description.abstract
This paper addresses the design of blood glucose control during the postprandial period for Type 1 diabetes patients. An artificial pancreas for ambulatory purposes has to deal with the delays inherent to the subcutaneous route, the carbohydrate intakes, the metabolic changes, the glucose sensor errors and noise, and the insulin pump constraints. A time response typically obtained in closed-loop insulin delivery shows hyperglycemia in the early postprandial period caused by the lag in the insulin absorbtion, followed by hypoglycemia caused by control over-reaction. A hybrid control system is proposed in this paper to overcome these problems. An insulin bolus is administered prior to the meals like in open-loop control, whereas a PD controller is used for robust glucose regulation. The controller gain is progressively increased after the bolus from zero up to its nominal value as function of the insulin on board, so that the PD controller becomes fully operational just when the insulin on board falls below a prescribed value. An excessive accumulation of active insulin is avoided in this way, drastically reducing the risk of hypoglycemia. The controller gain is adapted by means of a variable structure algorithm, allowing a very simple software implementation. The robust performance ofthe control algorithm is intensively assessed in silico on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, discrete measurement and actuation, sensor errors and other disturbances.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Artificial Pancreas
dc.subject
Glucose Control
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Hypoglycemia
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Insulin-On-Board
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Constrained Control
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Sliding Mode Control
dc.subject.classification
Ingeniería de Sistemas y Comunicaciones
dc.subject.classification
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-17T17:42:31Z
dc.journal.volume
8
dc.journal.number
6
dc.journal.pagination
724-736
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: León Vargas, Fabian. Universidad de Girona; España
dc.description.fil
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
dc.description.fil
Fil: de Battista, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
dc.description.fil
Fil: Vehí, Josep. Universidad de Girona; España
dc.journal.title
Biomedical Signal Processing And Control
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bspc.2013.06.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809413000931
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