Artículo
Surface layer proteins in species of the family Lactobacillaceae
Palomino, Maria Mercedes
; Allievi, Mariana Caludia
; Gordillo, Tania Belén
; Bockor, Sabrina Sol
; Fina Martin, Joaquina
; Ruzal, Sandra Mónica
Fecha de publicación:
02/2023
Editorial:
John Wiley & Sons
Revista:
Microbial Biotechnology
ISSN:
1751-7915
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The S-layer or surface layer protein (SLP) is the most ancient biological envelope, highly conserved in several Bacteria and Archaea. In lactic acid bacteria (LAB), SLP is only found in species belonging to the Lactobacillaceae family, many of them considered probiotic microorganisms. New reclassification of members within the Lactobacillaceae family (International Journal of Systematic and Evolutionary Microbiology, 2020, 70, 2782) and newly sequenced genomes demands an updated revision on SLP genes and domain organization. There is growing information concerning SLP occurrence, molecular biology, biophysical properties, and applications. Here, we focus on the prediction of slp genes within the Lactobacillaceae family, and specifically, on the neat interconnection between the two different modular SLP domain organizations and the new reclassified genera. We summarize the results in a concise tabulated manner to review the present knowledge on SLPs and discuss the most relevant and updated concepts regarding SLP sequence clustering. Our assessment is based on sequence alignments considering the new genera classification and protein domain definition with post-translational modifications. We analyse the difficulties encountered to resolve the SLPs 3D structure, describing the need for structure prediction approaches and the relation between protein structure and its anchorage mechanism to the cell wall. Finally, we enumerate new SLP applications regarding heterologous display, pathogen exclusion, immunostimulation, and metal binding.
Palabras clave:
S-layer
,
Lactobacillaceae
,
Domain organization
,
Applications
Archivos asociados
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Identificadores
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Palomino, Maria Mercedes; Allievi, Mariana Caludia; Gordillo, Tania Belén; Bockor, Sabrina Sol; Fina Martin, Joaquina; et al.; Surface layer proteins in species of the family Lactobacillaceae; John Wiley & Sons; Microbial Biotechnology; 16; 6; 2-2023; 1232-1249
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