Artículo
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
Gismondi, Maria Ines
; Díaz Carrasco, Juan María
; Valva, Pamela
; Becker, Pablo Daniel; Guzman, Carlos Alberto
; Campos, Rodolfo Hector
; Preciado, María Victoria
Fecha de publicación:
12/2013
Editorial:
Elsevier Inc
Revista:
Virology
ISSN:
0042-6822
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196
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