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dc.contributor.author
Gismondi, Maria Ines
dc.contributor.author
Díaz Carrasco, Juan María
dc.contributor.author
Valva, Pamela
dc.contributor.author
Becker, Pablo Daniel
dc.contributor.author
Guzman, Carlos Alberto
dc.contributor.author
Campos, Rodolfo Hector
dc.contributor.author
Preciado, María Victoria
dc.date.available
2017-05-02T19:25:40Z
dc.date.issued
2013-12
dc.identifier.citation
Gismondi, Maria Ines; Díaz Carrasco, Juan María; Valva, Pamela; Becker, Pablo Daniel; Guzman, Carlos Alberto; et al.; Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children; Elsevier Inc; Virology; 447; 1-2; 12-2013; 187-196
dc.identifier.issn
0042-6822
dc.identifier.uri
http://hdl.handle.net/11336/15891
dc.description.abstract
Classic phylogenetic and modern population-based clustering methods were used to analyze hepatitis C virus (HCV) evolution in plasma and to assess viral compartmentalization within peripheral blood mononuclear cells (PBMCs) in 6 children during 3.2–9.6 yr of follow-up. Population structure analysis of cloned amplicons encompassing hypervariable region 1 led to the distinction of two evolutionary patterns, one highly divergent and another one genetically homogeneous. Viral adaptability was reflected by co-evolution of viral communities switching rapidly from one to another in the context of divergence and stability associated with highly homogeneous communities which were replaced by new ones after long periods. Additionally, viral compartmentalization of HCV in PBMCs was statistically demonstrated, suggesting their role as a pool of genetic variability. Our results support the idea of a community-based structure of HCV viral populations during chronic infection and highlight a role of the PBMC compartment in the persistence of such structure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Compartmentalization
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Evolution
dc.subject
Hepatitis C Virus
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Pbmc
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Pediatric Infection
dc.subject
Population Structure
dc.subject.classification
Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Virología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-28T17:11:23Z
dc.journal.volume
447
dc.journal.number
1-2
dc.journal.pagination
187-196
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Gismondi, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Díaz Carrasco, Juan María. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Valva, Pamela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Becker, Pablo Daniel. Helmholtz Centre For Infection Research; Alemania
dc.description.fil
Fil: Guzman, Carlos Alberto. Helmholtz Centre For Infection Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Campos, Rodolfo Hector. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213005114
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.virol.2013.09.002
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