Artículo
Partial replacement of corn oil with chia oil into a high fat diet produces either beneficial and deleterious effects on metabolic and vascular alterations in rabbits
Alarcón, Gabriela del Jesús
; Medina, Analia; Martin Alzogaray, María Florencia; Sierra, Liliana del Carmen; Roco, Julieta
; Van Nieuwenhove, Carina Paola
; Medina, Mirta; Jerez, Susana Josefina
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Fecha de publicación:
12/2020
Editorial:
Elsevier
Revista:
PharmaNutrition
ISSN:
2213-4344
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: the beneficial effects of Salvia hispanica (chia) seed on metabolic parameters have been widely studied. However, there are little evidence about the effects of chia seed oil (ChO) on metabolic syndrome (MS). Thus, we aimed to evaluate the isocaloric partial replacement of corn oil with ChO into a high fat diet on metabolic parameters and vascular alterations in a model of MS. Methods: rabbits were fed either regular diet (CD); CD supplemented with 3% ChO (CD-Ch); CD supplemented with 8% lard and 10 % corn oil (HFD) or HFD in which 3% of corn oil was replaced with ChO (HFD-Ch), for 6 weeks. Results: HFD-Ch reduced the HFD-induced rise of triglycerides and n-6/n-3 fatty acids ratio. However, the deleterious effect of HFD on fasting glucose (FG), abdominal obesity and glucose tolerance was worsened. Reduction of palmitoleic acid level in plasma from HFD-Ch may account for worsening of FG. HFD-Ch reversed the HFD-induced endothelial dysfunction and sensitized aortic tissues to angiotensin II. Mechanism of such phenomenon may involve the lowest increase of linolenic acid levels in erythrocyte membranes from HFD-Ch compared to CD-Ch. Conclusion: partial replacement of corn oil with ChO into HFD produced both beneficial and harmful effects on MS.
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Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos(INBIOFAL)
Articulos de INSTITUTO DE BIOTECNOLOGÍA FARMACEUTICA Y ALIMENTARIA
Articulos de INSTITUTO DE BIOTECNOLOGÍA FARMACEUTICA Y ALIMENTARIA
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Alarcón, Gabriela del Jesús; Medina, Analia; Martin Alzogaray, María Florencia; Sierra, Liliana del Carmen; Roco, Julieta; et al.; Partial replacement of corn oil with chia oil into a high fat diet produces either beneficial and deleterious effects on metabolic and vascular alterations in rabbits; Elsevier; PharmaNutrition; 14; 12-2020; 1-7; 100218
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