Artículo
Redirection of the immune response to the functional catalytic domain of cruzipain improves protective immunity against Trypanosoma cruzi infection
Cazorla, Silvia Ines
; Frank, Fernanda Maria
; Becker, Pablo D.; Arnaiz, María; Mirkin, Gerardo Ariel Isidoro; Corral, Ricardo Santiago
; Guzman, Carlos Alberto
; Malchiodi, Emilio Luis
Fecha de publicación:
12/2010
Editorial:
Oxford University Press
Revista:
Journal Of Infectious Diseases
ISSN:
0022-1899
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Despite the strong immune responses elicited after natural infection with Trypanosoma cruzi or vaccination against it, parasite survival suggests that these responses are insufficient or inherently inadequate. T. cruzi contains a major cystein proteinase, cruzipain, which has a catalytic N-terminal domain and a C-terminal extension. Immunizations that employed recombinant cruzipain or its N- and C-terminal domains allowed evaluation of the ability of cruzipain to circumvent responses against the catalytic domain. This phenomenon is not a property of the parasite but of cruzipain itself, because recombinant cruzipain triggers a response similar to that of cruzipain during natural or experimental infection. Cruzipain is not the only antigen with a highly immunogenic region of unknown function that somehow protects an essential domain for parasite survival. However, our studies show that this can be reverted by using the N-terminal domain as a tailored immunogen able to redirect host responses to provide enhanced protection.
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Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Citación
Cazorla, Silvia Ines; Frank, Fernanda Maria; Becker, Pablo D.; Arnaiz, María; Mirkin, Gerardo Ariel Isidoro; et al.; Redirection of the immune response to the functional catalytic domain of cruzipain improves protective immunity against Trypanosoma cruzi infection; Oxford University Press; Journal Of Infectious Diseases; 202; 12; 12-2010; 136-144
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