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dc.contributor.author
Cazorla, Silvia Ines
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Frank, Fernanda Maria
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Becker, Pablo D.
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Arnaiz, María
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Mirkin, Gerardo Ariel Isidoro
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Corral, Ricardo Santiago
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Guzman, Carlos Alberto
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Malchiodi, Emilio Luis
dc.date.available
2017-03-15T20:20:44Z
dc.date.issued
2010-12
dc.identifier.citation
Cazorla, Silvia Ines; Frank, Fernanda Maria; Becker, Pablo D.; Arnaiz, María; Mirkin, Gerardo Ariel Isidoro; et al.; Redirection of the immune response to the functional catalytic domain of cruzipain improves protective immunity against Trypanosoma cruzi infection; Oxford University Press; Journal Of Infectious Diseases; 202; 12; 12-2010; 136-144
dc.identifier.issn
0022-1899
dc.identifier.uri
http://hdl.handle.net/11336/13925
dc.description.abstract
Despite the strong immune responses elicited after natural infection with Trypanosoma cruzi or vaccination against it, parasite survival suggests that these responses are insufficient or inherently inadequate. T. cruzi contains a major cystein proteinase, cruzipain, which has a catalytic N-terminal domain and a C-terminal extension. Immunizations that employed recombinant cruzipain or its N- and C-terminal domains allowed evaluation of the ability of cruzipain to circumvent responses against the catalytic domain. This phenomenon is not a property of the parasite but of cruzipain itself, because recombinant cruzipain triggers a response similar to that of cruzipain during natural or experimental infection. Cruzipain is not the only antigen with a highly immunogenic region of unknown function that somehow protects an essential domain for parasite survival. However, our studies show that this can be reverted by using the N-terminal domain as a tailored immunogen able to redirect host responses to provide enhanced protection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chagas Disease
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Immune Response
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Antigens
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Catalysis
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Catalytic Domain
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Endopeptidases
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Immunity
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Immunization
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Parasites
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Precipitating Factors
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Trypanosoma Cruzi
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Vaccination
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Vaccines
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Infection
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Mice
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Proteolytic Enzymes
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Redirection of the immune response to the functional catalytic domain of cruzipain improves protective immunity against Trypanosoma cruzi infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-14T15:02:41Z
dc.journal.volume
202
dc.journal.number
12
dc.journal.pagination
136-144
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Cazorla, Silvia Ines. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Helmholtz Centre for Infection Research; Alemania
dc.description.fil
Fil: Frank, Fernanda Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Becker, Pablo D.. Helmholtz Centre for Infection Research; Alemania
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Fil: Arnaiz, María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud; Argentina
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Fil: Mirkin, Gerardo Ariel Isidoro. Universidad de Buenos Aires. Facultad de Medicina; Argentina
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Fil: Corral, Ricardo Santiago. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Guzman, Carlos Alberto. Helmholtz Centre for Infection Research; Alemania. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina
dc.description.fil
Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Journal Of Infectious Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article-lookup/doi/10.1086/652872
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1086/652872
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