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Artículo

Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes

dos Santos, Cristina; Buera, Maria del PilarIcon ; Mazzobre, Maria FlorenciaIcon
Fecha de publicación: 11/2011
Editorial: John Wiley & Sons Ltd
Revista: Journal of the Science of Food and Agriculture
ISSN: 0022-5142
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica

Resumen

Background: Cyclodextrins (CDs) are able to enhance the solubility, stability and bioavailability of several bioactive hydrophobic compounds by complex formation. They can also be used for removal of undesired components (such as cholesterol, off-flavors or bitter components) present in foods. Although many patents account for the use of cyclodextrins for removal of cholesterol from dairy foods, there is no available information on the effect of water on encapsulation efficiency and on the stability of sterols in CDs. The aim of this work was to study the inclusion properties and the factors affecting the encapsulation and stability of cholesterol in β-cyclodextrin (BCD). The optimum encapsulation conditions (ligand-CD molar ratio, stirring time and temperature), and stability of the complexes as a function of storage time and water content were analyzed. Results: Phase solubility study pointed out the formation of 1:1 stoichiometric complexes between cholesterol and β-cyclodextrin, which was influenced by temperature variations. The process was shown to be exothermic and energetically favored. The presence of cholesterol greatly modified the BCD water sorption curves, being the amount of adsorbed water smaller in the combined systems. The principal 'driving force' for complex formation is the substitution of the high-enthalpy water molecules by an appropriate hydrophobic ligand. The freeze-dried complexes probed to be stable at different storage conditions. Conclusion: The phase solubility and stability data obtained could be essential for selecting the most suitable conditions when CDs are employed either for removing cholesterol or to incorporate functional ingredients (i.e. sitosterol) in the development of innovative food products.
Palabras clave: CHOLESTEROL , CYCLODEXTRIN , PHASE SOLUBILITY , STABILITY CONSTANTS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/113309
URL: http://onlinelibrary.wiley.com/doi/10.1002/jsfa.4425/abstract
DOI: http://dx.doi.org/10.1002/jsfa.4425
Colecciones
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
dos Santos, Cristina; Buera, Maria del Pilar; Mazzobre, Maria Florencia; Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 91; 14; 11-2011; 2551-2557
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