Biopharmaceutics drug disposition classification system

Abstract

The Biopharmaceutics Drug Disposition Classification System (BDDCS) is a revision of the Biopharmaceutics (or Biopharmaceutical) Classification System (BCS) that may be useful to predict routes of elimination and to foresee the effects of absorptive and efflux transporters on oral absorption and drug-drug interactions. It was conceived to predict the disposition characteristics of novel drugs (new molecular entities, NME). The fundamental idea of this derivative classification system is to replace permeability in the BCS by the extent of metabolism (by recognizing the strong correlation between these two properties).