Data set Assessment of testicular function in boys with hematological malignancies

Abstract

Survival rates after pediatric hematological malignancies have improved substantially, raising concerns about endocrine sequelae. While gonadotoxic effects on germ cells have been characterized in adult survivors, the early impact of cancer and chemotherapy on the hypothalamic-pituitary-testicular axis during childhood and adolescence has not yet been sufficiently studied. We conducted a prospective longitudinal cohort study with 63 children and adolescents with acute lymphoblastic leukemia, acute myeloid leukemia, or non-Hodgkin lymphoma, treated at a tertiary pediatric center in Argentina between 2013 and 2019. Hormonal markers of Sertoli cell function (AMH, inhibin B, FSH) and Leydig cell function (testosterone, LH) were serially evaluated from diagnosis, during chemotherapy, and up to 3 years after the end of treatment. This database includes hormone levels in the different study groups and their statistical comparisons.