Crystal and spectroscopic structure and biological activity of a new lapacholate complex with zinc(II), a potential antibacterial

Abstract

The solid-state molecular structure of dilapacholate (diaqua) zinc(II) bis(dimethylsulfoxide), for short [Zn(Lap)2(H2O)2]·2DMSO, was determined by X-ray diffraction methods. It crystallizes in the monoclinic space group P21/c with Z = 2 molecules per unit cell. The complex is at a crystallographic inversion center with the Zn(II) ion in a rectangular base bipyramidal environment of approximate D2h local symmetry, coordinated at the pyramid base to two lapacholate anions acting as bidentate ligands through their phenolic and adjacent carbonyl oxygen atoms and at the pyramid apexes to two water molecules. We report spectroscopic data on the vibrational and electronic structure of the complex and also its thermal properties. The new lapacholate complex exhibits antibacterial activity against several clinic strains of Staphylococcus aureus.