New actors in optic neuritis pathogenesis

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dc.conicet.fuenteCrossref
dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos
dc.conicet.paisOrganizacionArgentina
dc.conicet.produccionid8751155
dc.contributor.authorRosenstein, Ruth Estela
dc.date.accessioned2021-09-15T18:32:43Z
dc.date.available2021-09-15T18:32:43Z
dc.date.issued2020-03
dc.date.updated2021-09-07T18:56:30Z
dc.description.abstractThe aim of the present report was to analyze the involvement of glutamate neurotoxicity in retinal ganglion cell loss and optic nerve damage induced by experimental optic neuritis. For this purpose, the authors used an optic neuritis model induced by immunisation with myelin oligodendrocyte glycoprotein (AON). The authors describe a correlation in the timing of retinal ganglion cell (RGC) loss with alterations in the optic nerve actin cytoskeleton dynamic, and visual dysfunction. In addition, they show that an intravitreal injection of glutamate mimics, and an NMDA receptor antagonist avoids the effect of pre-clinical AON on visual functions and RGC number, as well as on optic nerve actin cytoskeleton. Taken together, their results support that avoiding glutamate neurotoxicity could become a new therapeutic approach for optic neuritis treatment.es
dc.description.filFil: Rosenstein, Ruth Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.formatapplication/pdfes
dc.identifier.citationRosenstein, Ruth Estela; New actors in optic neuritis pathogenesis; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 153; 6; 3-2020; 671-673es
dc.identifier.institucionalCONICET
dc.identifier.issn0022-3042es
dc.identifier.repoCONICET Digital
dc.identifier.urihttp://hdl.handle.net/11336/140430
dc.journal.ciudadLondreses
dc.journal.number6es
dc.journal.pagination671-673es
dc.journal.paisReino Unidoes
dc.journal.titleJournal of Neurochemistryes
dc.journal.volume153es
dc.language.isoenges
dc.publisherWiley Blackwell Publishing, Inces
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14991
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jnc.14991
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/*
dc.subjectoptic neuritises
dc.subjectoptic nervees
dc.subjectretinal ganglion celles
dc.subjectglutamatees
dc.subject.classificationNeurocienciases
dc.subject.classificationMedicina Básicaes
dc.subject.classificationCIENCIAS MÉDICAS Y DE LA SALUDes
dc.titleNew actors in optic neuritis pathogenesises
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion

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