Polyphenols as a Complementary Dietary Strategy in the Management of MASLD

Abstract

The alarming worldwide prevalence of non-alcoholic fatty liver disease (NAFLD), recently termed metabolic dysfunction-associated fatty liver disease (MASLD), and its pathophysiological, clinical, and socioeconomic implications have strongly encouraged research in this area in search of effective therapies to combat this disease. Following the recent conditional approval of resmetirom, the importance of a comprehensive treatment involving pharmacotherapy and lifestyle improvement is becoming increasingly evident. Including natural polyphenols in the diet could be a complementary strategy to reduce liver damage and the metabolic burden associated with MASLD.