A maternal diet enriched in olive oil prevents pro-inflammatory alterations in term placentas from diabetic pregnant women

Abstract

Gestational diabetes mellitus (GDM) induces a pro-inflammatory intrauterine environment and alters placental function. Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that regulate the expression of genes involved in antiinflammatory processes. Olive oil (OO) is enriched in oleic acid, a PPAR activator. We hypothesize that a maternal diet enriched in OO is capable of activating PPAR pathways and reducing pro-inflammatory markers in term placentas