Consequences of early life stress on the structure and function of the adult mouse retina

Abstract

Early-life stress (ELS) refers to a period of environmental/social deprivation, physical, sexual or emotional abuse, neglect, severe and/or chronic trauma in the prenatal/early postnatal stage, which is closely related to many adverse psychiatric disorders later in life, such as depressive disorder, substance abuse, dysthymia, panic, anxiety, and suicidal behavior in adulthood (Waters and Gould, 2022). In addition to moodrelated symptoms, a strong association between ELS and a wide range of adverse health outcomes in adulthood has been demonstrated, with increased risk of metabolic, musculoskeletal, neurological, respiratory, cardiovascular, and gastrointestinal symptoms (Wegman and Stetler, 2009)...