A commentary on the interplay of biomaterials and cell adhesion: new insights in bone tissue regeneration

Abstract

This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting theimportance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initialdescription of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explainingthe leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited.Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating thenative environment, taking advantage of these known specific signaling pathways. The final remarks lay on the needfor careful consideration of in-vitro and in-vivo complexities in biomaterial development.