Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?
; Fernandez, Claudio Oscar ; Valiente Gabioud, Ariel Alejandro ; Fernández, C. O. ; Rey, N. A. Otros responsables
Fecha
04/2015
Editorial
Royal Society of Chemistry
Revista
Metallomics
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ISSN
1756-5901
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Inglés
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Resumen
Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.
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Identificadores
Hauser Davis, R.A.; De Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, Marco César; et al.; Disruption of zinc and copper interactions with Ab(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer’s disease therapy?; Royal Society of Chemistry; Metallomics; 7; 5; 4-2015; 743-747
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