Topical antiinflamtory activity of Tripodanthus acutifolius flowers gel formulation

Abstract

This study evaluated a new herbal preparation containing extract from flower of Thripodanthus acutifolius “corpo” for its antiinflammatory activity against carrageenan induced edema. Gelling agent used was gel base (Carbopol 940®). The physicochemical appearance of the formulation was consistent, brilliant, dark amber, due to the color of the extract, without apparent loss of his structure during 60 days in conditions of rest. The gel was evaluated for various parameters such as stability, pH, spreadability, skin irritancy and organoleptic characters. Topical administration of corpo gel showed significant antiedematogenic activity. The maximal activity was 20 % at 2.5 h after carrageenan injection and maintained for 4.5 h of assay. The results concluded that topical preparation containing 4% of corpo gel possesses antiiflammatory effect which can be useful for the treatment of local inflammation.