Contribution of low-level image statistics to EEG decoding of semantic content in multivariate and univariate models with feature optimization

Abstract

Spatio-temporal patterns of evoked brain activity contain information that can be used to decode and categorize the semantic content of visual stimuli. However, this procedure can be biased by low-level image features independently of the semantic content present in the stimuli, prompting the need to understand the robustness of different models regarding these confounding factors. In this study, we trained machine learning models to distinguish between concepts included in the publicly available THINGS-EEG dataset using electroencephalography (EEG) data acquired during a rapid serial visual presentation paradigm. We investigated the contribution of low-level image features to decoding accuracy in a multivariate model, utilizing broadband data from all EEG channels. Additionally, we explored a univariate model obtained through data-driven feature selection applied to the spatial and frequency domains. While the univariate models exhibited better decoding accuracy, their predictions were less robust to the confounding effect of low-level image statistics. Notably, some of the models maintained their accuracy even after random replacement of the training dataset with semantically unrelated samples that presented similar low-level content. In conclusion, our findings suggest that model optimization impacts sensitivity to confounding factors, regardless of the resulting classification performance. Therefore, the choice of EEG features for semantic decoding should ideally be informed by criteria beyond classifier performance, such as the neurobiological mechanisms under study.