Advances in metal-mediated solid-phase synthesis of heterocyclic compounds

Abstract

While heterocycles are a key feature frequently found in compounds with pharmaceutical or agrochemical interest, the combination between solidsupported synthesis and organometallic chemistry has demonstrated to be a helpful tool for the preparation of that class of biologically relevant structures. From the more disclosed Hüisgen 1,3-dipolar cycloaddition, the palladium-catalyzed synthesis of indoles and the ruthenium carbene-mediated preparation of heterocycles by ring-closing metathesis (RCM), to the less developed use of gold and iron in polymer-supported chemistry, this survey offers an overview of the solid-phase application of metal-mediated chemistry to the generation of libraries of a variety of heterocyclic systems.