Simultaneous and orthogonal covalent exchange processes in dynamic combinatorial libraries

Abstract

In this work, we report the first example of a mixed strategy involving simultaneous and orthogonal covalent reactions in one single system through the combination of the exchange of disulfides, thioesters, and hydrazones. As a consequence of altering the activation order of the sequentially addressable processes, biased DCLs are obtained where the history of each DCL is manifested as distinct distribution of products.