Kidney liver pathophysiological crosstalk: its characteristics and importance

Abstract

The kidney plays a crucial role in controlling the blood volume and pressure, electrolyte and acid–base balance, erythropoietin secretion, as well as renin–angiotensin–aldosterone system activity. All these renal activities have important repercussion in the organism, explaining why morbidity and mortality rates are high in patients with significant renal dysfunction. In this sense, there are renal-induced liver damages in acute kidney injury, as well as liver-induced renal damages in hepatic disease. Ischemia, reperfusion, cytokine outflow, pro-inflammatory cascades, metabolic acidosis, oxidative stress, and changes in enzymatic and metabolic pathways provide the bases for this bidirectional kidney–liver damage. In conclusion, knowing the characteristics of this kidney–liver crosstalk is crucial for handling the complications induced by this vicious circle.