Biog5: A bioinformatic system for the analysis of the Human Papillomavirus

Abstract

Human papillomavirus (HPV) is classified according to its oncogenic potential intodifferent types of risk which are low, high and undetermined. Currently, there are more than 100 different types but just the most prevalent and high-risk ones (nine of them) are currently covered byavailable vaccines. In addition, there are several less common strains that can still cause cancer and be resistant to vaccines. Biog5 is a tool that integrates multiple computational biology and bioinformatics tools to find correlations between all requested HPV strains in sequence analysis and structural data of L1, L2, E1, E2 and E7 proteins. This allows us to assist in diagnostic and outbreak investigations to address the virulence and likelihood of vaccine resistance of the less prevalent strains.