Cases of severe acute liver injury following inactivated SARS-CoV-2 vaccination

Abstract

Several cases of severe acute liver injury (ALI) with features of autoimmune hepatitis after SARS-CoV-2 infection or SARSCoV-2 vaccination have been described.1–7 Most cases developed ALI following mRNA or viral vector-based vaccines, while only a few reports described the development of ALI after inactivated SARS-CoV-2 vaccines.1 Recently, Wong et al.8 evaluated the risk of ALI in a large cohort of vaccine recipients. They reported that the risk of ALI did not increase due to any formulation of SARS-CoV-2 vaccination. We reviewed our cohort of patients who developed ALI after inactivated SARS-CoV-2 vaccination.