Optimizing hypertension management: the impact of drug class, socioeconomic factors, and simplified regimens on medication adherence. VATAHTA study

Abstract

Background: Medication adherence is essential for managing hypertension, yet many patients fail to follow prescribed treatments. This study examines the relationships between drug class, treatment complexity, socioeconomic factors, and adherence in hypertensivepatients from Argentina.Methods: A multicentre, cross-sectional study was conducted with 1144 hypertensive patients from the Cuyoregion. Adherence was assessed using the Morisky Medication Adherence Scale (MMAS-8). The impact of drug classes, number of prescribed drugs, dosing frequency, and socioeconomic factors (education, home ownership, employment status) on adherence was analysed using multivariate logistic regression. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.Results: Patients on fixed-dose combinations demonstrated better adherence than those on monotherapy (OR 1.30, 95% CI: 1.15–1.45). Highereducation (OR 1.20, 95% CI: 1.05–1.35) and home ownership (OR 1.15, 95% CI: 1.02–1.28) were associated with improved adherence, while unemployment was linked to reduced adherence. Patients taking more than three drugs showed lower adherence (OR 0.85, 95% CI: 0.75–0.95), and more frequent dosing (more than twice daily) was linked to reduced adherence (OR 0.78, 95% CI: 0.68–0.90). Beta-blockers (OR 2.5, 95% CI: 2.0–3.0) and potassium-sparing diuretics (OR 1.7, 95% CI: 1.3–2.1) were associated with the highest adherence, while ACE inhibitors such as ramipril (OR 0.75, 95% CI: 0.60–0.90) were linked to lower adherence.Conclusion: Simplified regimens, particularly fixed-dose combinations, and the selection of drugs with favourable adherence profiles, like beta-blockers and potassiumsparing diuretics, can improve adherence. Addressing socioeconomic barriers should also be prioritized.