Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses

Abstract

Little is known regarding the mechanisms involved in the clock-immunity crosstalk. de Leone et al. report that the defense mutant eds4 carries a mutation in NUCLEOPORIN205 which affects its circadian function, and that leads to an attenuation of the transcriptional reprogramming in core clock genes that take place soon after a bacterial infection.