Microbial synthesis of 2,6-diaminopurine nucleosides

Abstract

2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2 -deoxyriboside, -2 ,3 -dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2 ,3 -dideoxyriboside catalysed by whole cells is here reported for the first time.