Piroxicam-Loaded Nanostructured Lipid Nanocarriers Modified with Salicylic Acid: The Effect on Drug Release

Abstract

Piroxicam-loaded nanostructured lipid carriers modified with salicylic acid (SA) were developed. The modified system showed similar properties to the previously studied lipid carriers without the acid incorporation but it presents more dynamic characteristics. SA favored the interaction between nanoparticles which was reflected in a size increase in a shorter time. As well, there was a close relationship between the size increase and the drug release performance. Square wave voltammetry was selected as an alternative technique to study the drug release. In vitro studies showed that the nanocarrier system modification caused a piroxicam (PX) fast release, reducing the analysis times. Also, it was observed an increase on the drug release percentage, obtaining values of up to 93 %. Thus, the modified system is able to control and improve the PX release. These results bring out the carrier system versatility, modifying the lipid matrix it is possible to modulate the drug release parameters.