Ubiquitin-proteasome signaling in lung injury

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dc.conicet.fuenteindividual
dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres
dc.conicet.organizacionNorthwestern University
dc.conicet.organizacionNorthwestern University
dc.conicet.organizacionNorthwestern University
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.produccionid8783299
dc.contributor.authorMagnani, Natalia Daniela
dc.contributor.authorDada, Laura Andrea
dc.contributor.authorSznajder, Jacob I.
dc.date.accessioned2022-07-04T15:36:29Z
dc.date.available2022-07-04T15:36:29Z
dc.date.issued2018-08
dc.date.updated2022-06-21T19:30:04Z
dc.description.abstractCell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.es
dc.description.filFil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Northwestern University; Estados Unidos
dc.description.filFil: Dada, Laura Andrea. Northwestern University; Estados Unidos
dc.description.filFil: Sznajder, Jacob I.. Northwestern University; Estados Unidos
dc.formatapplication/pdfes
dc.identifier.citationMagnani, Natalia Daniela; Dada, Laura Andrea; Sznajder, Jacob I.; Ubiquitin-proteasome signaling in lung injury; Elsevier Science Inc.; Translational Research; 198; 8-2018; 29-39es
dc.identifier.institucionalCONICET
dc.identifier.issn1931-5244es
dc.identifier.repoCONICET Digital
dc.identifier.urihttp://hdl.handle.net/11336/161156
dc.journal.pagination29-39es
dc.journal.paisEstados Unidoses
dc.journal.titleTranslational Researches
dc.journal.volume198es
dc.language.isoenges
dc.publisherElsevier Science Inc.es
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1931524418300574
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.trsl.2018.04.003
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/*
dc.subjectUbiquitines
dc.subjectLung injuryes
dc.subjectProteosome signalinges
dc.subject.classificationBiología Celular, Microbiologíaes
dc.subject.classificationCiencias Biológicases
dc.subject.classificationCIENCIAS NATURALES Y EXACTASes
dc.titleUbiquitin-proteasome signaling in lung injuryes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion

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