Artículo

Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells

Fernández, Marisa Mariel Icon; Ferragut, Fátima Icon; Cardenas Delgado, Victor Manuel Icon; Bracalente, María Candelaria Icon; Bravo, Alicia Ines ; Cagnoni, Alejandro Icon; Nuñez, Myriam Carmen ; Morosi, Luciano Gastón Icon; Quintá, Héctor Ramiro Icon; Espelt, Maria Victoria Icon; Troncoso, María Fernanda Icon; Wolfenstein, Carlota Elisa Icon; Mariño, Karina Valeria Icon; Malchiodi, Emilio Luis Icon; Rabinovich, Gabriel Adrián Icon; Elola, Maria Teresa Icon

Otros responsables

Fecha

2016-04-26

Editorial

Elsevier Science

Revista

Biochimica et Biophysica Acta- General Subjects

Título del libro

Nombre del evento

Fecha del evento

Institución organizadora

ISSN

0304-4165

eISSN

1878-2434

ISBN

Idioma

Inglés

Tipo del evento

Resumen

We previously demonstrated that the activated leukocyte cell adhesion molecule (ALCAM/CD166) can interact with galectin-8 (Gal-8) in endothelial cells. ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell-cell interactions. Gal-8 is a "tandem-repeat"-type galectin, known as a matricellular protein involved in cell adhesion. Here, we analyzed the physical interaction between both molecules in breast cancer cells and the functional relevance of this phenomenon.

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