The Yin and Yang of Histamine in the regulation of testicular Leydig cell proliferation

Abstract

Histamine (HA) is a biogenic amine with indisputable significance for medicine and biology. It is synthesized exclusively by histidine decarboxylase (HDC) in all mammalian tissues, albeit tissue-specific mechanisms operate to keep its concentration within strict limits: both a deficit of HA or a slight excess can lead to health loss. With regard to the male gonad, previous studies have linked increased mast cell numbers and mast-cell related HA with the pathogenesis of infertility.