Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes

Abstract

Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer’s patches. We show here that newborn mice lacking 7 integrin or Lselectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer’s patch lymphocytes in wildtype mice were 7 and 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.